Prof. Andrés Eduardo Carrasco (MD)
Laboratorio Embriología Molecular
Instituto Biología Celular y Neurociencias
Facultad de Medicina. Universidad de Buenos Aires.
Paraguay 2155 3er piso. Buenos Aires 1121
The study of the genetic control of embryogenesis in Vertebrates
began to flourish in the eighties with the isolation of the first
Hox gene in the amphibian Xenopus laevis (Carrasco et al., 1984).
With the frog embryo as the main model, we have been dedicated to
delve into the relationship between retinoids and Hox genes in the
morphogenesis of the anterior-posterior axis (López et al.,
1992, 1995). More recently, we extended our studies to Sonic Hedgehog
and Notch signalling in relation to early neurogenesis and the development
of the embryonic dorsal midline (Franco et al., 1999; Paganelli
et al., 2001; López et al., 2003, 2005).
Development is a complex process that integrates multiple
cellular mechanisms such as differentiation, proliferation, programmed
cell death and cell movements, which must be finely coordinated
in space and time to achieve the proper array of cells, tissues
and organs. We are particularly interested in how these processes
are orchestrated and modulated by molecular signals to pattern and
configure the shape and size of the central nervous system and the
mesoderm during early development in Xenopus.